Hearts of Oak will begin their defense of the Ghana Premier League title with an opening match against Legon Cities at the Accra Sports Stadium.
The Phobians completed the double last season after winning the 2020/21 Ghana premier league and MTN FA Cup.
The new campaign is scheduled to commence on Friday, 29th October 2021 and end on June 19th 2022.
However, the league will break after the first round which ends on February 13th 2022 and resume on February 25th.
Last season, Hearts of Oak drew 1-1 with Legon Cities in the first round before winning the reverse fixture 2-1 thanks to first half goals from Kwadwo Obeng Jr. and Frederick Ansah Botchway.
Victoria Adebayor scored the consolation for the Royals.